We report herein a case of lymphomatoid papulosis showing atypical clinical manifestations. A 54-year-old man had had recurrent erythematous necrotic papules and nodules, numbering more than 200 lesions at the most aggravated time, on the trunk,
extremities, buttock, and face for the last twenty years. Recently, he complained or tender swelling on the neck, axillae, and inguinal lymph nodes accompanied by mild fever and general weakness. We had performed thorough examinations including
biopsy
form the skin lesions, lymph node, and bone marrow to detect some evidences of transforming to malignant lymphoma, but found no evidence of malignant lymphoma except aneuploidy on DNA histogram. The patients showed prompt response to methotrexate
10-30mg per week without showing distinct side reactions to the accumulated dose of 780mg for the last 16 months.
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